The VXI-MXI interface is a C-size extended class mainframe extender for the VXIbus (VMEbus Extensions for Instrumentation). It extends the VXIbus architecture outside a VXIbus mainframe via the MXIbus (Multisystem Extension Interface bus). A VXIbus mainframe equipped with a VXI-MXI can be transparently connected to other MXIbus devices such as other VXIbus mainframes, MXIbus instruments, or MXIbus-equipped personal computers. The VXI-MXI interface module uses address mapping to transparently translate bus cycles on the VXIbus system bus (VMEbus) to the MXIbus and vice versa.

The MXIbus is a multidrop system bus that connects multiple devices at the hardware bus level in a software-transparent manner. Multiple VXIbus mainframes with VXI-MXI interfaces can be connected to form a single multiframe VXIbus system. An external PC with a MXIbus interface can also be connected to a VXIbus mainframe with a VXI-MXI. This configuration makes the PC appear to be embedded on a VXIbus module that is plugged into the VXIbus mainframe.

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